Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). Although it is known that striatal spiny projection neurons (SPNs) are involved in the genesis of this mov...

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Main Authors: Heiman, Myriam (Contributor), Heilbut, Adrian (Author), Francardo, Veronica (Author), Kulicke, Ruth (Contributor), Fenster, Robert (Contributor), Kolaczyk, Eric D. (Author), Mesirov, Jill P. (Author), Surmeier, Dalton J. (Author), Cenci, M. Angela (Author), Greengard, Paul (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-11-06T19:47:53Z.
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