Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator of cell growth, survival, and autophagy. Deregulation of the PI3K/Akt/mTOR signaling pathway occurs commonly in cancer and numerous inhibitors targeting the ATP-binding site of these kinases are currently u...

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Main Authors: Liu, Qingsong (Author), Xu, Chunxiao (Author), Kirubakaran, Sivapriya (Author), Zhang, Xin (Author), Hur, Wooyoung (Author), Kwiatkowski, Nicholas P. (Author), Wang, Jinhua (Author), Westover, Kenneth D. (Author), Gao, Peng (Author), Ercan, Dalia (Author), Niepel, Mario (Author), Thoreen, Carson C. (Author), Kang, Seong A. (Author), Patricelli, Matthew P. (Author), Wang, Yuchuan (Author), Tupper, Tanya (Author), Altabef, Abigail (Author), Kawamura, Hidemasa (Author), Held, Kathryn D. (Author), Chou, Danny M. (Author), Elledge, Stephen J. (Author), Janne, Pasi A. (Author), Wong, Kwok-Kin (Author), Gray, Nathanael S. (Author), Sabatini, David (Author), Liu, Yan (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2015-04-23T19:36:17Z.
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