Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella

Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella

Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction-modification (R-M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R-M systems, highly partial PT modification of consensus motifs i...

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Bibliographic Details
Main Authors: Cao, Bo (Contributor), Cheng, Qiuxiang (Author), Gu, Chen (Contributor), Yao, Fen (Author), DeMott, Michael S. (Contributor), Zheng, Xiaoqing (Author), Deng, Zixin (Author), Dedon, Peter C. (Contributor), You, Delin (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2015-10-15T13:41:39Z.
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