THE ROLE OF ALDEHYDE DEHYDROGRENASE 2 IN NITRATE TOLERANCE: INVESTIGATION OF LOW POTENCY NITRATES AND CROSS TOLERANCE
Organic nitrates such as glyceryl trinitrate (GTN) are commonly used to treat cardiovascular disease. They are prodrugs that require bioactivation for pharmacological activity. Currently, there are two proposed pathways of organic nitrate activation: a high-affinity pathway for high-potency nitrates...
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| Language: | en en |
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2011
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| Online Access: | http://hdl.handle.net/1974/6536 |