Mutational Analysis of the HIV-1 Tat Protein and its Role in Downregulating CD127 on CD8 T Cells
HIV Tat protein downregulates surface expression of the interleukin-7 receptor alpha-chain (CD127) on CD8 T cells resulting in impaired T cell proliferation and cytolytic capacity. Once taken up by CD8 T cells, Tat binds directly to the cytoplasmic tail of CD127 inducing receptor internalization and...
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| Language: | en |
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2013
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| Online Access: | http://hdl.handle.net/10393/24024 |