Mechanisms of Action and Relative Efficacy of Glucocorticosteroid Treatment in Ameliorating Immune Thrombocytopenia Induced by Anti-platelet GPIbα Versus GPIIbIIIa Immune Responses
Immune thrombocytopenia (ITP) is an autoimmune disorder, mediated mainly by autoantibodies against platelet glycoprotein GPIIbIIIa and GPIbα resulting in enhanced platelet destruction. Decreased platelet production and cellular immunity also contribute to ITP. GPIIbIIIa and GPIbα are distinct platel...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/42899 |