Conformationally rigidified inhibitors of human farnesyl pyrophosphate synthase
The mevalonate pathway is important in all eukaryotic cells. One of the key enzymes in this pathway is the human farnesyl pyrophosphate synthase (hFPPS), which has a pivotal role in cell prenylation. Nitrogen containing bisphosphonates (N-BPs) are a class of drugs that have been shown to effectively...
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| Format: | Others |
| Language: | en |
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McGill University
2014
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123177 |