DNA Topoisomerases I from Pseudomonas Aeruginosa and Vaccinia Virus and Their Use as Drug Targets
Pseudomonas aeruginosa encodes a putative topoisomerase with sequence similarity to the type IB topoisomerase enzyme from vaccinia virus. Residues in the active site are conserved, notably Tyr292 which would be predicted to form the transient covalent bond to DNA. The gene encoding the P. aeruginosa...
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| Format: | Others |
| Language: | en |
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LSU
2009
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| Online Access: | http://etd.lsu.edu/docs/available/etd-01202009-104542/ |