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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ysu13399647942021-08-03T06:18:11Z Analysis of Electrokinetic Flow in Microfluidic Chips Aryal, Sanket Biomedical Engineering Chemical Engineering Mechanical Engineering Electrokinetic Flow Comsol Electroosmosis Microfluidics Lab-on-chips Miniaturization and integration of conventional bioassay laboratory procedures into the micro-fabricated Lab-On-Chips (LOCs), usually referred to as ”Micro Total Analysis (μTAS) systems”, have tremendous impacts in the fields of genomics, proteomics, and other clinical analysis. Electrokinetically driven flow offers efficiently and effectively to control flow in micro devices without a need for any mechanical components. These bioanalytical microsystems utilize electrokinetic mobility including electroosmosis and electrophoresis modes for transport, mixing, manipulation, separation and detection of sample analytes. LOCs are already proven to significantly reduce analysis time and sample volume sizes without requiring a skilled worker to operate. In addition, LOCs are inexpensive, versatile, robust as well as portable. At the solid surfaces of the microchannel walls, an oppositely charged thin layer is formed separate from the bulk solutions of the sample analytes and buffer solutions. This thin layer is referred to as an “Electrical Double Layer (EDL)” or simply called “Debye's Thickness Layer”. Based on the type and material of the electrode surface, it is formed either by negatively or positively charged ionic groups from the bulk solution at the wall's surfaces. Using commercially available finite element software, called “COMSOL Multiphysics”, the electric field is modeled in such a way that it displaces EDL formed by ionic liquid leading to generate an electrokinetic flow in the microchannel. <i>MEMS (Micro-electromechanical systems) and Chemical Engineering Modules</i> of COMSOL are employed to model, physics set up, and simulate the ionic fluid flow for the analysis of fluid propulsion and chemical mass transport for the various physical models of microchips. The ionic fluid concentrations and velocities are plotted against the potential differences across the sample inlet vs. the outlet and across the buffer inlet vs. the outlet, respectively. Based on the COMSOL Multiphysics simulation results, it was concluded that the T-shaped microfluidic chip with a narrowed cross sectional area at the analysis chamber has maximum ionic velocity that increases with increase in electric potential for the EDL (Zeta potential) formed. Ionic concentration could be accumulated at the outlet by achieving higher concentrations with the electrophoresis mode. Thus, velocity and concentration distributions in the microfluidic chip could be manipulated by varying shape and size of the chips, varying potential differences between two inlets vs. outlet and varying zeta potential at the microchannel wall. In this thesis work, LOCs with microchannels were analyzed with varying parameters of electrical, chemical, and physical properties and proven their effects on the concentrations and the velocities of the sample analytes. 2012-06-20 English text Youngstown State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ysu1339964794 http://rave.ohiolink.edu/etdc/view?acc_num=ysu1339964794 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomedical Engineering
Chemical Engineering
Mechanical Engineering
Electrokinetic Flow
Comsol
Electroosmosis
Microfluidics
Lab-on-chips
spellingShingle Biomedical Engineering
Chemical Engineering
Mechanical Engineering
Electrokinetic Flow
Comsol
Electroosmosis
Microfluidics
Lab-on-chips
Aryal, Sanket
Analysis of Electrokinetic Flow in Microfluidic Chips
author Aryal, Sanket
author_facet Aryal, Sanket
author_sort Aryal, Sanket
title Analysis of Electrokinetic Flow in Microfluidic Chips
title_short Analysis of Electrokinetic Flow in Microfluidic Chips
title_full Analysis of Electrokinetic Flow in Microfluidic Chips
title_fullStr Analysis of Electrokinetic Flow in Microfluidic Chips
title_full_unstemmed Analysis of Electrokinetic Flow in Microfluidic Chips
title_sort analysis of electrokinetic flow in microfluidic chips
publisher Youngstown State University / OhioLINK
publishDate 2012
url http://rave.ohiolink.edu/etdc/view?acc_num=ysu1339964794
work_keys_str_mv AT aryalsanket analysisofelectrokineticflowinmicrofluidicchips
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