Study on monocationic Tc99m labeled ethylene imine phenol-

• Main Authors: Lin, Tzung Cheng, 林宗成
• Other Authors: Lo Jem Mau
• Format: Others
• Language: zh-TW
• Published: 1994
• Online Access: http://ndltd.ncl.edu.tw/handle/04555114109385205395

碩士 === 國立清華大學 === 原子科學研究所 === 82 === In this study, a series of ethylene imine phenol ligands,En( IP)2 [ethylene imine phenol],MEn(IP)2 [methylene imine phenol], DEn(IP)2 [dimethylethyl- ene imine phenol], Ch(IP)2 [cyclohexylethylene im- ine phenol] were synthesized. By means of mixing 99mTcO4- saline solution and SnCl2/ethanol solut- ion with the imine phenol ligands and heating at 95 oC for 15 min, a serial 99mTc labeled imine phenol complex [99mTcLO]+ were formed, where L re- presents the ethylene imine phenol ligands. Subsequently, phosphine or phosphite compound, P(CH3)3,P(OCH3)3 or P(OC2H5)3 was added and heated at 50oC for 45 min to reduce the technetium in the previously formed 99mTc coordinated ethylene imine phenols from Tc(V) to Tc(III). A stable mono- cationic and lipophilic 99mTc labeled phosphine ethylene imine phenol compound [99mTcLY2]+ (Y re- presents the phosphine or phosphite compound)would be obtained by the procedure.The chemical charact- eristics of the [99mTcLO]+ or [99mTcLY2]+ complexes were asseyed by solvent extraction, electrophoresis and high performance liquid chromatography.Labeling efficiency, lipophilicity,electrical charge and sat- bility of each of the [99mTcLY2]+ complexes were obtained from the analytical results. Among these 99mTc labeled complexes,[99mTc-DEn(IP) 2-Pom]+ shows the most promising chemical property as myocardial imaging agent. Rat biodistribution study of this complex also reveals a high myocard- ium uptake (~16.21 %cpm/g) and a stable retention in 3 hr. It is concluded from the study that [99m Tc-DEn(IP)2-Pom]+ exhibits the potential to be furthermore evaluated as a clinical myocardial perfusion agent.