Urinary 1-hydroxypyrene of school children in the vicinity of a medical waste incinerator

• Main Authors: Ming-Jyh Chen, 陳明志
• Other Authors: I-Fang Mao
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/39772153730774781041

碩士 === 國立陽明大學 === 環境衛生研究所 === 89 === Incineration is the general method to deal with medical waste. Through incineration, medical waste containing plenty of plastic products would produce high level of Polycyclic Aromatic Hydroycarbons (PAH), and this pollutant has health adverse effect to residents. In the past related studies, most of these focused on the measurement of ambient concentration of PAH, and rarely discussed the internal dose. The purpose of this study is to investigate the urinary 1-hydroxypyrene (1-OHP) concentration of residents living near a medical waste incinerator. In order to exclude other factors which may contribute urinary 1-OHP, including occupational and lifestyle,the junior high students from school A which near incinerator are selected as exposure group, and children from school B which has 15 km distance from the incinerator and has similar urbanization to A school are the control group. Urine samples were collected in the morning and evening, and measured urinary 1-OHP by the method developed by Jongeneelen. 1-OHP in urine was separated by HPLC with mobile phase gradient and then detected by a fluorescence detector. The urinary 1-OHP concentration was corrected by urinary creatinine. The mean concentration of urinary 1-OHP in the children of school A was 0.05 ± 0.08 mg/g creatinine in April morning, and 0.34 ± 0.61 mg/g creatinine for the evening samples. (p<0.05) In November, the mean 1-OHP concentration was 0.17 ± 0.36 mg/g creatinine in school A students and 0.11 ± 0.16 mg/g creatinine in school B students for the morning, (p>0.05) and it was 0.13 ± 0.2 and 0.11 ± 0.14 mg/g creatinine for the evening samples of A and B school, respectively.(p>0.05) In univariable analysis, 1-OHP concentration of students was not different in two schools in November. In multiple regression analysis, the mean urinary 1-OHP concentration of school A children was significantly higher than that of school B children (p<0.05) after controlling other variables. Because school A locates at downwindside in April and upwindside in November, urinary 1-OHP concentration of school A children in April was significant higher than that in November (p<0.05) in the evening. We also found that the urinary 1-OHP concentration of school A children in April was higher than that of school B children in November. This study showed that the school children nearby the medical waste incinerator had higher urinary 1-OHP, which should contribute to the PAHs exposure caused by the incinerator emission.