| Summary: | 碩士 === 國立中山大學 === 生物醫學科學研究所 === 92 === To elucidate the correlation between host susceptible genes and the carcinogenesis of gastric cancer and duodenal ulcer, myeloperoxidase (MPO) -463 G/A polymorphism was detected by PCR-RFLP and nucleotide autosequencing, respectively. On the other hand, E-cadherin (CDH1) -160 C/A polymorphism was analyzed by nucleotide autosequencing. No positive correlation among MPO genotype distributions, gastric cancer (p=0.26, ��2=2.73) and duodenal ulcer (p=0.99, ��2=0.03) was found after age-and-sex adjusted. Helicobacter pylori-positive gastric cancer patients with GA genotype have higher cancer risk (ORs: 1.19, 95% CI=0.41-2.65) before age-and-sex adjusted. On the other hand, correlation between CDH1 genotype distribution and diffuse-type gastric cancer was not found (p=0.81, ��2=0.42). Furthermore, CDH1 -160 C/A polymorphism is not significantly correlated with metastasis (p=0.09, ��2=0.96). In conclusion, the two polymorphisms were not appropriate genetic markers of gastric cancer.
|
|---|
