The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation
碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 93 === The combination of Fluorouracil (5-Fu) and Folinic acid (Leucovorin) is the first line regiment for colorectal caner. Sometimes these two drugs are mixed in the same container for the convenience of using in our hospital. In addition, patients can be treated...
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Others |
Language: | zh-TW |
Published: |
2005
|
Online Access: | http://ndltd.ncl.edu.tw/handle/34332879331893239066 |
id |
ndltd-TW-093KMC05551006 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-TW-093KMC055510062015-10-13T13:08:18Z http://ndltd.ncl.edu.tw/handle/34332879331893239066 The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation Fluorouracil與Leucovorin配伍之微粒數目評估 Chia-Ling Kuo 郭嘉翎 碩士 高雄醫學大學 藥學研究所碩士在職專班 93 The combination of Fluorouracil (5-Fu) and Folinic acid (Leucovorin) is the first line regiment for colorectal caner. Sometimes these two drugs are mixed in the same container for the convenience of using in our hospital. In addition, patients can be treated with multiple days continuous infusion without hospitalized, because of the progressing medical supplies. However, the study has shown that these two drugs are physically incompatible. Furthermore, more studies have showed that the particles of injections are potentially harmful for body. The pharmacopoeias in many countries have made a precise standard for the particles in large volume parenterals (LVPs). The U.S.P. also has made a precise standard for small volume parenterals (SVPs) recently, but it is performed by HIAC® method. Meanwhile, the Chinese pharmacopoeia does not make up a standard for SVPs yet. The aim of this study was to detect the particulate contaminant of samples by Coulter Counter®. The concentrations of 5-Fu and Leucovorin were based on the clinical dosage. The data of the particulate count were collected after four hours of preparing and determination of the count of particles was carried out from second day to seventh day. According to the assumption of “One-Fifth Theory” and the standard for LVPs in Chinese pharmacopoeia, patients can endure the consequence in particular situation. Moreover, medical staffs can care their patients more effectively and patients’ hospitalization both frequency and duration can be reduced. Finally, the goal of this study is that medical staffs can provide high efficiency medical service and patients can have a higher quality of medical attention. Thau-Ming Cham 詹道明 2005 學位論文 ; thesis 72 zh-TW |
collection |
NDLTD |
language |
zh-TW |
format |
Others
|
sources |
NDLTD |
description |
碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 93 === The combination of Fluorouracil (5-Fu) and Folinic acid (Leucovorin) is the first line regiment for colorectal caner. Sometimes these two drugs are mixed in the same container for the convenience of using in our hospital. In addition, patients can be treated with multiple days continuous infusion without hospitalized, because of the progressing medical supplies. However, the study has shown that these two drugs are physically incompatible. Furthermore, more studies have showed that the particles of injections are potentially harmful for body. The pharmacopoeias in many countries have made a precise standard for the particles in large volume parenterals (LVPs). The U.S.P. also has made a precise standard for small volume parenterals (SVPs) recently, but it is performed by HIAC® method. Meanwhile, the Chinese pharmacopoeia does not make up a standard for SVPs yet.
The aim of this study was to detect the particulate contaminant of samples by Coulter Counter®. The concentrations of 5-Fu and Leucovorin were based on the clinical dosage. The data of the particulate count were collected after four hours of preparing and determination of the count of particles was carried out from second day to seventh day.
According to the assumption of “One-Fifth Theory” and the standard for LVPs in Chinese pharmacopoeia, patients can endure the consequence in particular situation. Moreover, medical staffs can care their patients more effectively and patients’ hospitalization both frequency and duration can be reduced. Finally, the goal of this study is that medical staffs can provide high efficiency medical service and patients can have a higher quality of medical attention.
|
author2 |
Thau-Ming Cham |
author_facet |
Thau-Ming Cham Chia-Ling Kuo 郭嘉翎 |
author |
Chia-Ling Kuo 郭嘉翎 |
spellingShingle |
Chia-Ling Kuo 郭嘉翎 The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation |
author_sort |
Chia-Ling Kuo |
title |
The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation |
title_short |
The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation |
title_full |
The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation |
title_fullStr |
The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation |
title_full_unstemmed |
The Compatibility of Fluorouracil with Leucovorin on Particulate Evaluation |
title_sort |
compatibility of fluorouracil with leucovorin on particulate evaluation |
publishDate |
2005 |
url |
http://ndltd.ncl.edu.tw/handle/34332879331893239066 |
work_keys_str_mv |
AT chialingkuo thecompatibilityoffluorouracilwithleucovorinonparticulateevaluation AT guōjiālíng thecompatibilityoffluorouracilwithleucovorinonparticulateevaluation AT chialingkuo fluorouracilyǔleucovorinpèiwǔzhīwēilìshùmùpínggū AT guōjiālíng fluorouracilyǔleucovorinpèiwǔzhīwēilìshùmùpínggū AT chialingkuo compatibilityoffluorouracilwithleucovorinonparticulateevaluation AT guōjiālíng compatibilityoffluorouracilwithleucovorinonparticulateevaluation |
_version_ |
1717732780809388032 |