The Serum Concentration of Cardiac Troponin I in Association of Dogs with Chronic Degenerative Valvular Diseases

• Main Authors: Shih-Wan Wang, 汪士琬
• Other Authors: Hui-Pi Huang
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/98825995578199509099

碩士 === 國立臺灣大學 === 獸醫學研究所 === 97 === Biomarkers have been extensively used in human and veterinary medicine, and divided into two groups: the leakage markers and functional makers. Cardiac troponin I (cTnI), a structure protein of cardiomyocyte, is a sensitive, specific, is a leakage marker for cardiac injury. N-terminal-pro B-type natriuretic peptide (NT-proBNP), a hormone exerts a variety of effects of maintaining circulatory homeostasis in states of increased extracellular volume, is a functional maker. The thesis includes two sections: first part, association NT-proBNP and cTnI of clinically healthy dogs and dogs with heart failure (HF); second part, changes of cTnI concentrations before and after treatment for HF. The result of this study illustrated that concentrations of NT-proBNP and cTnI in the dogs with HF were higher than those in the control dogs (P<0.001, P=0.02, respectively), and these two cardiac makers were positively associated with severity of HF (P<0.0001, P=0.02, respectively). Serum cTnI concentrations decreased after treatment, but not reach significant different (P=0.09). Based on these findings, both cardia markers were able to identify presence of cardiac disease, and determine severity of HF in dogs.