Association between Metabolic Syndrome and Bone Mineral Density in Taiwanese Women

• Main Authors: Yue-Yuan Lee, 李悅源
• Other Authors: 程蘊菁
• Format: Others
• Language: en_US
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/41692416493365936232

碩士 === 國立臺灣大學 === 流行病學與預防醫學研究所 === 100 === Background Osteoporosis (OP) is a major public health issue because of it has been linked to increased fracture risk and the subsequent mortality. Metabolic syndrome (MetS) has been related to several health issues. However, the association between MetS and BMD has been inconsistent and no previous study has explored how menopausal status modified this association. Methods A total of 1,577 Taiwanese women aged 40 to 55 years old were recruited from the MJ Health Screening Center between 2009 and 2010. Bone mineral density (BMD, g/cm2) was measured at the lumbar spine by using dual-energy X-ray absorptiometry (DXA) and were tertiled (T1, T2, and T3). MetS is based on the definition from ATP III report with modification for the Asian criteria for waist circumference and fasting glucose. High BMD was defined as T2 plus T3, low BMD was defined as T1. This study was aimed to explore the association between MetS or individual component of MetS and BMD in Taiwanese women. We also explored how menopausal status or other potential confounders modified this association. Results Women with MetS had a decreased risk of low BMD [adjusted OR (AOR) = 0.32, 95% confidence interval (CI) = 0.19-0.56]. Women with abdominal obesity (AOR = 0.54, 95% CI = 0.35-0.84), high blood pressure (BP, AOR = 0.63, 95% CI = 0.43-0.94), or high fasting glucose (AOR = 0.66, 95% CI = 0.48-0.90) had a decreased risk of low BMD. Menopausal status did not significantly modify the association of each individual components of MetS (P interaction >0.05), or MetS itself, with BMD. Conclusions Women with MetS, abdominal obesity, high BP, or fasting glucose were significantly associated with a decreased risk of low BMD. Menopausal status did not significantly modify the associations between MetS or individual components of MetS and the risk of low BMD.