The Effect of Adipose-derived Stem Cell and Amniotic Membrane Co-culture System in Periodontal Bone Regeneration

• Main Authors: Pin-Hsien Wu, 吳品嫻
• Other Authors: Cheng-Chi Chang
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/26892536754437193767

碩士 === 國立臺灣大學 === 口腔生物科學研究所 === 101 === Periodontal disease is a chronic inflammatory reaction of periodontal tissues that potentially leads to tooth loss. It can affect daily activity, such as chewing and speech. Unfortunately, there is no effective therapy for periodontal disease. Use of tissue engineering technologies and stem cell therapy on Periodontal bone regeneration is a very promising treatment. Adipose-derived stem cell has been proved to its multipotency and have significant outcome in many disorders. Amniotic membrane is anti-inflammation, anti-angiogenic, low immunogenicity, and enriched with growth factor. We create a co-culture system with adipose-derived stem cell and amniotic membrane in periodontal osseous defect of rat model. The result suggest that the co-culture system could enhance periodontal bone regeneration. We believed this study could provide the base of the co-culture system as stem cell therapy and amniotic membrane transplantation in clinical periodontology.