Used Overt naming fMRI to detect the change between pre- and post- rTMS treatment on post-stroke aphasic patients’ brain cortex.

• Main Authors: Yu-Chun Liao, 廖于甄
• Other Authors: Wen-Hsu Sung
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/12785767991983250378

碩士 === 國立陽明大學 === 物理治療暨輔助科技學系 === 101 === Background: The recovery of post-stroke aphasia is very slowly even treated after many years. Currently, repetitive transcranial magnetic stimulation (rTMS) is a new method to treat the brain cortex by interfering with threshold induced voltage on language area to bring about a new compensatory area. However, different native speakers might have different compensatory region, but it rarely focuses on Chinese speakers, and never investigated the changes of brain cortex between they were cured by rTMS. Purposes: By combining non-invasive functional magnetic resonance imaging (fMRI) with rTMS on expressing-impaired Chinese patient, we intended to figure out: (1) The change of languages-related cortex on the patients who was nonfluent aphasia and had been treated for two weeks. (2) Compare the brain imaging of language-related regions on the health as before. Methods: Each patient received ten, 1-Hz rTMS treatments and evaluated by Concise Chinese Aphasia Test (CCAT), modified S&;V picture naming test, and the rear-fMRI test. There were audible language tasks and the items contained picture naming, semantic decision and sentence completion. We also separated the first one to noun-naming and verb-naming. Finally, general linear modeling was used to analyze every exam by Statistical Parametric Mapping 8 software, and statistical significance was set at p<.001 with uncorrected. Results and Discussion: In this study we find out two things. First, the word-category differences affect language performance on the Chinese-aphasic patient, because the performance was bad when it has verb-related component in any behavioral test and it was particularly worse in picture naming test. Second, the language-compensation was on contralateral brain instead of the other side after they were cured by low-rTMS. Conclusions: The compensatory areas for impaired language function emerged homologous from the contralateral hemisphere after receiving LF-rTMS, and that were symmetric difference between aphasic stroke patients and the health. If the language function was high, Chinese aphasia patient will have homologous regions in the right hemisphere after LF-rTMS treatment.