Drug Repurposing via Connectivity Map

• Main Authors: Shao-Wei Chang, 張少薇
• Other Authors: Chi-Ying F. Huang
• Format: Others
• Language: en_US
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/72716552576220066924

碩士 === 國立陽明大學 === 生物藥學研究所 === 101 === Therapy of cancer is an important question needed to be solved, but many anti-neoplastic agents are facing to dilemma of discovery, such as too much cytotoxicity and taking a long time to place a drug into market. Drug repurposing is one of the approaches to tackling the challenges. Moreover, drug repurposing may substantially increase the number and quality of innovative, cost-effective new medicines, without incurring unsustainable R&;D costs. In this project, I aim to analyze drugs from the Connectivity Map (CMap) and design strategy of literature review to understand situation of drug repurposing of focused drugs in this thesis. Briefly, there are 1309 drugs in CMap and 443 of them are in National Health Insurance Research Database (NHIRD). There are FDA-labeled indications, Non FDA-labeled indications, literature review, patent survey, clinical trials in the strategy. According to this strategy, we can understand the patent situation of drug repurposing of focused drugs, including anti-psychotic agents and several novel compounds. Many potential anti-neoplastic agents have seen tested in clinical trials and have not been patented. In conclusion, drug discovery of anti-neoplastic agents through drug repurposing is highly promising.