Selective Inhibition and Mechanistic Studies of the Human O2 Sensor, Prolyl Hydroxylase Domain 2 (PHD2)

Prolyl Hydroxylase Domain 2 (PHD2) has been identified as a key oxygen sensor in humans along with Factor Inhibiting Hypoxia Inducible Factor (FIH). As such PHD2 and FIH play critical roles in myriad pathways of medical relevance by hydroxylation of their target substrate hypoxia inducible factor (H...

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Bibliographic Details
Main Author: Flagg, Shannon Coates
Format: Others
Published: ScholarWorks@UMass Amherst 2011
Subjects:
Online Access:https://scholarworks.umass.edu/open_access_dissertations/460
https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1458&context=open_access_dissertations