Theoretical Studies of Anti-cancer Drug Tamoxifen and Estrogen Receptor Alpha
For decades tamoxifen (TAM) has been widely used for treatment of breast cancer by mediating mainly the estrogen receptor α (ERα) signaling pathways, whereby it suppresses estrogen stimulated cancer cell growth. The clinical response of TAM has been linked to cytochrome P450 2D6 (CYP2D6), which is t...
| Main Author: | |
|---|---|
| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
KTH, Teoretisk kemi och biologi
2012
|
| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-105721 http://nbn-resolving.de/urn:isbn:978-91-7501-586-6 |