Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

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Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted...

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Bibliographic Details
Main Author: Clarin, Leona
Format: Others
Language:English
Published: KTH, Tillämpad fysikalisk kemi 2020
Subjects:
Unbound concentration
free concentration
ultrafiltration
LC-MS/MS
cefotaxime
flucloxacillin
cloxacillin
piperacillin
Fri fraktion
ultrafiltrering
cefotaxim
flukloxacillin
kloxacillin
Analytical Chemistry
Analytisk kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-287570

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-287570

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