Design and synthesis of aspartyl protease inhibitors : Targeting HIV-1 and malaria plasmepsin I and II
Aspartyl proteases can generally be inhibited by peptide mimics containing an uncleavable peptide bond isostere at the proposed cleavage site. One such peptide bond isostere is the hydroxyethylamine moiety, which in this thesis has successfully been incorporated in potential inhibitors of the HIV-1-...
| Main Author: | |
|---|---|
| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
Uppsala universitet, Institutionen för läkemedelskemi
2003
|
| Subjects: | |
| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3288 http://nbn-resolving.de/urn:isbn:91-554-5527-1 |