DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY

Many of the diseases associated with glycoprotein variation can be more effectively treated with earlier detection substantiating the need for high-throughput methodologies for glycoconjugate characterization. This remains particularly difficult due to heterogeneity, branching, and large size of car...

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Main Author:	Fenn, Larissa Spell
Other Authors:	Prof. Daniel C. Liebler
Format:	Others
Language:	en
Published:	VANDERBILT 2010
Subjects:	Chemistry
Online Access:	http://etd.library.vanderbilt.edu/available/etd-04122010-131814/

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spelling	ndltd-VANDERBILT-oai-VANDERBILTETD-etd-04122010-1318142013-01-08T17:16:36Z DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY Fenn, Larissa Spell Chemistry Many of the diseases associated with glycoprotein variation can be more effectively treated with earlier detection substantiating the need for high-throughput methodologies for glycoconjugate characterization. This remains particularly difficult due to heterogeneity, branching, and large size of carbohydrate moieties which makes them less amenable to conventional proteomic methods. The specific aim of this research is to develop intelligent strategies for the characterization of glycans and glycoconjugates using rapid (us to ms) structural separations by ion mobility and subsequent identification by mass spectrometry in pursuit of simultaneous glycomic, lipidomic, and proteomic characterization from complex biological samples. Prof. Daniel C. Liebler Prof. Brian O. Bachmann Prof. Richard N. Armstrong Prof. John A. McLean VANDERBILT 2010-04-12 text application/pdf http://etd.library.vanderbilt.edu/available/etd-04122010-131814/ http://etd.library.vanderbilt.edu/available/etd-04122010-131814/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection	NDLTD
language	en
format	Others
sources	NDLTD
topic	Chemistry
spellingShingle	Chemistry Fenn, Larissa Spell DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY
description	Many of the diseases associated with glycoprotein variation can be more effectively treated with earlier detection substantiating the need for high-throughput methodologies for glycoconjugate characterization. This remains particularly difficult due to heterogeneity, branching, and large size of carbohydrate moieties which makes them less amenable to conventional proteomic methods. The specific aim of this research is to develop intelligent strategies for the characterization of glycans and glycoconjugates using rapid (us to ms) structural separations by ion mobility and subsequent identification by mass spectrometry in pursuit of simultaneous glycomic, lipidomic, and proteomic characterization from complex biological samples.
author2	Prof. Daniel C. Liebler
author_facet	Prof. Daniel C. Liebler Fenn, Larissa Spell
author	Fenn, Larissa Spell
author_sort	Fenn, Larissa Spell
title	DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY
title_short	DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY
title_full	DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY
title_fullStr	DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY
title_full_unstemmed	DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY
title_sort	detection and characterization of glycans and glycoconjugates using ion mobility-mass spectrometry
publisher	VANDERBILT
publishDate	2010
url	http://etd.library.vanderbilt.edu/available/etd-04122010-131814/
work_keys_str_mv	AT fennlarissaspell detectionandcharacterizationofglycansandglycoconjugatesusingionmobilitymassspectrometry
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DETECTION AND CHARACTERIZATION OF GLYCANS AND GLYCOCONJUGATES USING ION MOBILITY-MASS SPECTROMETRY

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