MECHANISMS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE ACTIVATION AND NUCLEAR TRAFFICKING
In several growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for tyrosine kinase activation. Using alanine scanning mutagenesis, I define a domain within the JM region of the epidermal growth factor receptor (EGFR)...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2009
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-09022009-164115/ |