Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs
Paclitaxel was isolated from the bark of <i>Taxus brevifolia</i> in the late 1960s. It exerts its biological effect by promoting tubulin polymerization and stabilizing the resulting microtubules. Paclitaxel has become one of the most important current drugs for the treatment of breast an...
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Virginia Tech
2014
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| Online Access: | http://hdl.handle.net/10919/28942 http://scholar.lib.vt.edu/theses/available/etd-09112008-083828/ |