Drug Solubilization using N-Methyl Pyrrolidone: Efficiency and Mechanism
The solubilization efficiency of N-methyl pyrrolidone (NMP) has been determined and compared to that of ethanol and propylene glycol for 13 poorly soluble drugs. NMP is a more efficient solubilizer for all these drugs. The solubility enhancement as high as about 800-fold is obtained in 20% v/v NMP s...
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| Language: | EN |
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The University of Arizona.
2006
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| Online Access: | http://hdl.handle.net/10150/194616 |