Class I Lysine Deacetylases Facilitate Glucocorticoid-Mediated Gene Activation and Repression

Class I Lysine Deacetylases Facilitate Glucocorticoid-Mediated Gene Activation and Repression

Lysine acetyltransferases (KATs) and lysine deacetylases (KDACs) are known to cooperate with the glucocorticoid receptor (GR) to regulate transcription. The current model of GR-mediated transcription classifies KATs as coactivators as they acetylate histones to form an open chromatin conformation an...

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Bibliographic Details
Main Author: Patrick, Nina M.
Other Authors: Smith, Catharine L.
Language:en_US
Published: The University of Arizona. 2015
Subjects:
Gene Activation
Gene Repression
Glucocorticoid Receptor
KDAC
LSD1
Pharmaceutical Sciences
Deacetylase
Online Access:http://hdl.handle.net/10150/594555

Internet

http://hdl.handle.net/10150/594555

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