Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line.

Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line.

Increases in the expression of prostaglandin E2 (PGE2) are widely known to be involved in aberrant growth in the early stage of colon cancer development. We herein demonstrated that the novel indole compound MW-03 reduced PGE2-induced cAMP formation by catalization to an inactive metabolite by induc...

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Bibliographic Details
Main Authors: Seira, Naofumi, Yanagisawa, Naoki, Suganami, Akiko, Honda, Takuya, Wasai, Makiko, Regan, John W, Fukushima, Keijo, Yamaguchi, Naoto, Tamura, Yutaka, Arai, Takayoshi, Murayama, Toshihiko, Fujino, Hiromichi
Other Authors: Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol
Language:en
Published: PHARMACEUTICAL SOC JAPAN 2017
Subjects:
indole compound
MW-03
prostaglandin E-2
15-hydroxyprostaglandin dehydrogenase
peroxisome proliferator-activated receptor-gamma
colon cancer
Online Access:http://hdl.handle.net/10150/626040
http://arizona.openrepository.com/arizona/handle/10150/626040

Internet

http://hdl.handle.net/10150/626040
http://arizona.openrepository.com/arizona/handle/10150/626040

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