Activity of Adenoviral E1A CR2 Deletion Mutants in Ovarian Cancer
d1922-947 is a type 5 adenovirus deleted in a portion of its genome, EIA CR2, which releases E2F by binding retinoblastoma protein (PRb). Transactivation of E2Fresponsive genes stimulates S phase entry and viral DNA is preferentially replicated. Since over 90% of human cancers have pRb pathway abnor...
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Queen Mary, University of London
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504564 |