Short term effects of c-MYC activation on β-cell physiology and glucose homeostasis in the pIns-c-MycERTAM transgenic mouse
Injection of 4-hydroxytamoxifen (4-OHT) activates the oncogene c-myc in transgenic pIns-c-MycERTAM mice, triggering β-cell proliferation in the short term as well as apoptosis and reduced insulin secretion, leading to hyperglycaemia. This hyperglycaemia is preceded by a short period of hypoglycaemia...
Main Author: | Wang, Yi-Fang |
---|---|
Published: |
University of Warwick
2012
|
Subjects: | |
Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560310 |
Similar Items
-
Avian telomere dynamics
by: Foote, Christopher Graham
Published: (2009) -
Hearing and acoustic interaction in mosquitoes
by: Warren, Ben
Published: (2011) -
Relationships between environmental conditions, energetic strategies and performance in juvenile Atlantic salmon, Salmo salar
by: Reid, Donald
Published: (2012) -
The nervous control of melanophores in the minnow (Phoxinus phoxinus L.) and other teleosts, with special reference to the effects of adrenergic drugs and light intensity
by: Amiri, Mohammed Hadi
Published: (1979) -
Internal defence mechanisms in Patella
by: Cooper-Willis, Anwyl
Published: (1978)