Application of chemically modified oligonucleotides in nanopore sensing and DNA nano-biotechnology

This thesis describes how targeted chemical modification can enhance the properties of nucleic acids for use in (i) nanopore analytics and (ii) nanobiotechnology. In nanopore analytics, individual molecules are detected as they pass a nanoscale pore to give rise to detectable blockades in ionic curr...

Full description

Bibliographic Details
Main Author: Mitchell, N. J.
Published: University College London (University of London) 2010
Online Access: