The role of hypoxia-induced RRM2B in DNA replication
Regions of low oxygen (hypoxia) occur in most solid tumours and correlate with poor patient prognosis due to their resistance to chemo- and radiotherapy and to their increased metastatic potential. Severe levels of hypoxia induce DNA replication stress characterised by an increased number of stalled...
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University of Oxford
2016
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730312 |