Investigating the role of the secreted tumour suppressor Dickkopf-3 in stromal-epithelial interactions in prostate cancer
DKK3 is a tumour suppressor gene encoding a secreted protein, Dkk-3, which is found in benign prostate and prostate cancer stroma. Dkk-3 maintains normal prostate epithelial acinar morphogenesis by limiting TGF-β/Smad/matrix metalloproteinase signalling. The role of stromal Dkk-3 was investigated in...
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Imperial College London
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.739666 |