An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models

INTRODUCTION: Arthrofibrosis, which occurs in a substantial portion of the population, is a pathologic accumulation of scar tissue that presents in patients as a painful decrease in joint range of motion. Since an individual’s quality of life can be significantly impacted by arthrofibrosis and becau...

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Main Author: Okajima, Stephen Michael
Language:en_US
Published: 2017
Subjects:
Online Access:https://hdl.handle.net/2144/23876
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spelling ndltd-bu.edu-oai-open.bu.edu-2144-238762019-04-03T10:19:22Z An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models Okajima, Stephen Michael Medicine Arthrofibrosis Contracture Histology Range of motion Relaxin Shoulder INTRODUCTION: Arthrofibrosis, which occurs in a substantial portion of the population, is a pathologic accumulation of scar tissue that presents in patients as a painful decrease in joint range of motion. Since an individual’s quality of life can be significantly impacted by arthrofibrosis and because there are limitations in current treatments, this thesis focuses on examining the use of the hormone relaxin to alleviate shoulder arthrofibrosis. METHODS: A set of 20 Sprague Dawley rats were given secondary shoulder contractures and separated into groups to examine the efficacy of relaxin using intravenous delivery, intra-articular delivery, and different treatment frequencies. The differences across groups were examined through mechanical range of motion testing as well as histologic sampling. RESULTS: Multiple doses of intra-articular injections of relaxin showed a complete return to the normal range of motion (P < 0.01) when compared with the surgical control, whereas other delivery methods and frequencies failed to show meaningful improvements. This was further confirmed in histologic analysis through the lack of fibrotic adhesions within the capsular space after multiple intra-articular relaxin treatments when compared with the surgical control. DISCUSSION: Although significant improvements to range of motion were seen after multiple doses of intra-articular relaxin, potential tissue degradation was also observed within the joint space after histologic examination. Further research is necessary to fully understand the proper dosing needed to avoid potential negative side effects caused by excess use of relaxin. 2017-09-22T15:53:13Z 2017-09-22T15:53:13Z 2017 2017-07-13T19:26:31Z Thesis/Dissertation https://hdl.handle.net/2144/23876 en_US Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
collection NDLTD
language en_US
sources NDLTD
topic Medicine
Arthrofibrosis
Contracture
Histology
Range of motion
Relaxin
Shoulder
spellingShingle Medicine
Arthrofibrosis
Contracture
Histology
Range of motion
Relaxin
Shoulder
Okajima, Stephen Michael
An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models
description INTRODUCTION: Arthrofibrosis, which occurs in a substantial portion of the population, is a pathologic accumulation of scar tissue that presents in patients as a painful decrease in joint range of motion. Since an individual’s quality of life can be significantly impacted by arthrofibrosis and because there are limitations in current treatments, this thesis focuses on examining the use of the hormone relaxin to alleviate shoulder arthrofibrosis. METHODS: A set of 20 Sprague Dawley rats were given secondary shoulder contractures and separated into groups to examine the efficacy of relaxin using intravenous delivery, intra-articular delivery, and different treatment frequencies. The differences across groups were examined through mechanical range of motion testing as well as histologic sampling. RESULTS: Multiple doses of intra-articular injections of relaxin showed a complete return to the normal range of motion (P < 0.01) when compared with the surgical control, whereas other delivery methods and frequencies failed to show meaningful improvements. This was further confirmed in histologic analysis through the lack of fibrotic adhesions within the capsular space after multiple intra-articular relaxin treatments when compared with the surgical control. DISCUSSION: Although significant improvements to range of motion were seen after multiple doses of intra-articular relaxin, potential tissue degradation was also observed within the joint space after histologic examination. Further research is necessary to fully understand the proper dosing needed to avoid potential negative side effects caused by excess use of relaxin.
author Okajima, Stephen Michael
author_facet Okajima, Stephen Michael
author_sort Okajima, Stephen Michael
title An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models
title_short An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models
title_full An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models
title_fullStr An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models
title_full_unstemmed An in vivo improvement of range of motion in shoulder contractures with relaxin in animal models
title_sort in vivo improvement of range of motion in shoulder contractures with relaxin in animal models
publishDate 2017
url https://hdl.handle.net/2144/23876
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