Unraveling the link between the Mdm2-p53 axis and aging
The transcription factor p53 is an important master regulator of the cellular response to stress. Mdm2 is an E3 ubiquitin ligase that is the primary negative regulator of p53. Mdm2 downregulates p53 activity through three mechanisms: proteasome-mediated degradation, exportation from the nucleus, and...
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| Language: | English |
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2017
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| Online Access: | https://doi.org/10.7916/D85Q57GW |