Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis

Synthesis of charged cyclodextrin highly soluble in organic solvents was made by exchanging the inorganic counter ion (Na+) of heptakis (2,3-di-Omethyl- 6-O-sulfo)-β-CD (Na7HDMS) with tetrabutylammonium (TBA+), to produce TBA7HDMS. The same ion exchange was used to synthesize the TBA salts of the...

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Main Author: Maldonado, Omar
Other Authors: Vigh, Gyula
Format: Others
Language:en_US
Published: Texas A&M University 2006
Subjects:
Online Access:http://hdl.handle.net/1969.1/4211
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spelling ndltd-tamu.edu-oai-repository.tamu.edu-1969.1-42112013-01-08T10:38:23ZSynthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresisMaldonado, OmarcyclodextrinSynthesis of charged cyclodextrin highly soluble in organic solvents was made by exchanging the inorganic counter ion (Na+) of heptakis (2,3-di-Omethyl- 6-O-sulfo)-β-CD (Na7HDMS) with tetrabutylammonium (TBA+), to produce TBA7HDMS. The same ion exchange was used to synthesize the TBA salts of the analogous CDs TBA6HxDMS and TBA8ODMS. Indirect-UV detection capillary electrophoresis (CE) and 1H NMR were used as the characterization methods. Separations of thirteen pharmaceuticals were made using TBA7HDMS as the chiral resolving agent in aqueous CE. On the other hand, a set of twenty pharmaceuticals was used for the enantiomer separations in non-aqueous CE (NACE). Comparison between the results obtained with TBA7HDMS in aqueous and non-aqueous CE were made. In addition, comparison between the results obtained with TBA7HDMS and Na7HDMS in aqueous and non-aqueous CE were made as well.Texas A&M UniversityVigh, Gyula2006-10-30T23:25:16Z2006-10-30T23:25:16Z2005-082006-10-30T23:25:16ZBookThesisElectronic Thesistext1247817 byteselectronicapplication/pdfborn digitalhttp://hdl.handle.net/1969.1/4211en_US
collection NDLTD
language en_US
format Others
sources NDLTD
topic cyclodextrin
spellingShingle cyclodextrin
Maldonado, Omar
Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
description Synthesis of charged cyclodextrin highly soluble in organic solvents was made by exchanging the inorganic counter ion (Na+) of heptakis (2,3-di-Omethyl- 6-O-sulfo)-β-CD (Na7HDMS) with tetrabutylammonium (TBA+), to produce TBA7HDMS. The same ion exchange was used to synthesize the TBA salts of the analogous CDs TBA6HxDMS and TBA8ODMS. Indirect-UV detection capillary electrophoresis (CE) and 1H NMR were used as the characterization methods. Separations of thirteen pharmaceuticals were made using TBA7HDMS as the chiral resolving agent in aqueous CE. On the other hand, a set of twenty pharmaceuticals was used for the enantiomer separations in non-aqueous CE (NACE). Comparison between the results obtained with TBA7HDMS in aqueous and non-aqueous CE were made. In addition, comparison between the results obtained with TBA7HDMS and Na7HDMS in aqueous and non-aqueous CE were made as well.
author2 Vigh, Gyula
author_facet Vigh, Gyula
Maldonado, Omar
author Maldonado, Omar
author_sort Maldonado, Omar
title Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
title_short Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
title_full Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
title_fullStr Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
title_full_unstemmed Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
title_sort synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
publisher Texas A&M University
publishDate 2006
url http://hdl.handle.net/1969.1/4211
work_keys_str_mv AT maldonadoomar synthesisofchargedcyclodextrinhighlysolubleinorganicsolventsforenantiomerseparationsincapillaryelectrophoresis
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