Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis

Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins, and some antimicrobial peptides. In this work, I show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 minutes....

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Bibliographic Details
Main Author: Carlisle, Matthew David
Other Authors: Brogden, Kim A.
Format: Others
Language:English
Published: University of Iowa 2010
Subjects:
Online Access:https://ir.uiowa.edu/etd/651
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1836&context=etd