Chemically Active Odorants as Olfactory Probes

The initial step in odor recognition by the nose is the binding of odorant molecules to receptor sites embedded in the dendritic membranes of olfactory receptor cells. Despite considerable interest and experimentation into the nature of these receptor sites, little is known of their specificity to d...

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Bibliographic Details
Main Author: Criswell, Darrell W. (Darrell Wayne)
Other Authors: Schafer, Rollie
Format: Others
Language:English
Published: North Texas State University 1982
Subjects:
Online Access:https://digital.library.unt.edu/ark:/67531/metadc331058/
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spelling ndltd-unt.edu-info-ark-67531-metadc3310582020-07-15T07:09:31Z Chemically Active Odorants as Olfactory Probes Criswell, Darrell W. (Darrell Wayne) olfactory responses chemically active odorants odorant molecules odor recognition Smell -- Physiological aspects. Deodorization. The initial step in odor recognition by the nose is the binding of odorant molecules to receptor sites embedded in the dendritic membranes of olfactory receptor cells. Despite considerable interest and experimentation into the nature of these receptor sites, little is known of their specificity to different types of odorant molecules. This lack of knowledge partially stems from the fact that the nature of receptor proteins is most effectively studied when specific and irreversible inhibitors are available for use as chemical probes, yet no such agents have been discovered for use in the olfactory system. A series of alkylating agents and other chemically active odorants were tested to determine whether they might react with specific odorant receptors and modify olfactory responses. Electroolfactogram (EOG) recordings were obtained before, during, and after treatment of the olfactory mucosae of grass frogs (Rana pipiens) with a chemically active odorant. North Texas State University Schafer, Rollie Mrotek, James J. Gross, Guenter W. Redden, David R. Busbee, David L. Beitinger, Thomas L. 1982-05 Thesis or Dissertation vi, 135 leaves : ill. Text local-cont-no: 1002782559-Criswell call-no: 379 N81d no. 1829 untcat: b1248403 oclc: 10656422 https://digital.library.unt.edu/ark:/67531/metadc331058/ ark: ark:/67531/metadc331058 English Public Criswell, Darrell W. (Darrell Wayne) Copyright Copyright is held by the author, unless otherwise noted. All rights reserved.
collection NDLTD
language English
format Others
sources NDLTD
topic olfactory responses
chemically active odorants
odorant molecules
odor recognition
Smell -- Physiological aspects.
Deodorization.
spellingShingle olfactory responses
chemically active odorants
odorant molecules
odor recognition
Smell -- Physiological aspects.
Deodorization.
Criswell, Darrell W. (Darrell Wayne)
Chemically Active Odorants as Olfactory Probes
description The initial step in odor recognition by the nose is the binding of odorant molecules to receptor sites embedded in the dendritic membranes of olfactory receptor cells. Despite considerable interest and experimentation into the nature of these receptor sites, little is known of their specificity to different types of odorant molecules. This lack of knowledge partially stems from the fact that the nature of receptor proteins is most effectively studied when specific and irreversible inhibitors are available for use as chemical probes, yet no such agents have been discovered for use in the olfactory system. A series of alkylating agents and other chemically active odorants were tested to determine whether they might react with specific odorant receptors and modify olfactory responses. Electroolfactogram (EOG) recordings were obtained before, during, and after treatment of the olfactory mucosae of grass frogs (Rana pipiens) with a chemically active odorant.
author2 Schafer, Rollie
author_facet Schafer, Rollie
Criswell, Darrell W. (Darrell Wayne)
author Criswell, Darrell W. (Darrell Wayne)
author_sort Criswell, Darrell W. (Darrell Wayne)
title Chemically Active Odorants as Olfactory Probes
title_short Chemically Active Odorants as Olfactory Probes
title_full Chemically Active Odorants as Olfactory Probes
title_fullStr Chemically Active Odorants as Olfactory Probes
title_full_unstemmed Chemically Active Odorants as Olfactory Probes
title_sort chemically active odorants as olfactory probes
publisher North Texas State University
publishDate 1982
url https://digital.library.unt.edu/ark:/67531/metadc331058/
work_keys_str_mv AT criswelldarrellwdarrellwayne chemicallyactiveodorantsasolfactoryprobes
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