CREATION OF A MOUSE WITH A HUMANIZED fpgs GENE COMPATIBLE WITH NORMAL DEVELOPMENT
Abstract: Folylpoly-γ-glutamate synthetase (FPGS) catalyzes the formation of polyglutamate forms of the reduced folates and antifolates such as methotrexate (MTX) and pemetrexed; this allows the retention of folates and antifolate cancer drugs inside the cell. The enzyme activity of FPGS is essenti...
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| Format: | Others |
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VCU Scholars Compass
2008
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| Online Access: | http://scholarscompass.vcu.edu/etd/1644 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2643&context=etd |