ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro

ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro

The migration of CD4+ effector/memory T cells across the blood–brain barrier (BBB) is a critical step in MS or its animal model, EAE. T-cell diapedesis across the BBB can occur paracellular, via the complex BBB tight junctions or transcellular via a pore through the brain endothelial cell body. Maki...

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Bibliographic Details
Main Authors: Barcos, S. (Author), Bruggmann, R. (Author), Deutsch, U. (Author), Engelhardt, B. (Author), Francisco, D. (Author), Gruber, I. (Author), Haghayegh Jahromi, N. (Author), Lyck, R. (Author), Marchetti, L. (Author), Pareja, J.R (Author), Soldati, S. (Author), Thiriot, A. (Author), von Andrian, U. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
animal
Animals
blood brain barrier
blood group Duffy system
Blood-Brain Barrier
CD4+ T lymphocyte
CD4-Positive T-Lymphocytes
cell surface receptor
Dfy protein, mouse
Duffy Blood-Group System
Encephalomyelitis, Autoimmune, Experimental
experimental autoimmune encephalomyelitis
genetics
immunology
inflammation
Inflammation
knockout mouse
Memory T Cells
memory T lymphocyte
Mice
Mice, Knockout
mouse
multiple sclerosis
Multiple Sclerosis
Receptors, Cell Surface
transendothelial and transepithelial migration
Transendothelial and Transepithelial Migration
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