Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis

Background and Aims: The “gut homing” hypothesis suggests the pathogenesis of primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut adhesion molecules and subsequent recruitment of gut-derived T cells to the liver. However, inconsistencies lie within this theory includ...

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Bibliographic Details
Main Authors:	Abu Arqoub, H. (Author), Graham, J.J (Author), Hayee, B. (Author), Heaton, N. (Author), Heneghan, M.A (Author), Huang, X. (Author), Huang, Z. (Author), Liberal, R. (Author), Longhi, M.S (Author), Ma, Y. (Author), McPhail, M. (Author), Mieli-Vergani, G. (Author), Mukherjee, S. (Author), Patel, V. (Author), Sanabria Mateos, R. (Author), Si, T. (Author), Vergani, D. (Author), Yuksel, M. (Author), Zen, Y. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2022
Subjects:	Antigens, CD beta chemokine beta integrin beta7 integrin cadherin Cadherins CCL25 protein, human CD4+ T lymphocyte CD4-Positive T-Lymphocytes CD8+ T lymphocyte CD8-Positive T-Lymphocytes CDH1 protein, human cell adhesion molecule Cell Adhesion Molecules Chemokines, CC Cholangitis, Sclerosing classification G protein coupled receptor gastrointestinal tract Gastrointestinal Tract gene expression profiling Gene Expression Profiling GPR15 protein, human human Humans immunohistochemistry Immunohistochemistry immunology Integrin beta Chains isolation and purification leukocyte antigen liver Liver liver disease Liver Diseases MADCAM1 protein, human metabolism mucoprotein Mucoproteins pathology receptor Receptors, G-Protein-Coupled Receptors, Peptide sclerosing cholangitis
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Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis

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