ROCK2-induced metabolic rewiring in diabetic podocytopathy

ROCK2-induced metabolic rewiring in diabetic podocytopathy

Loss of podocytes is a common feature of diabetic renal injury and a key contributor to the development of albuminuria. We found that podocyte Rho associated coiled-coil containing protein kinase 2 (ROCK2) is activated in rodent models and patients with diabetes. Mice that lacked ROCK2 only in podoc...

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Bibliographic Details
Main Authors: Aizawa, D. (Author), Ikegami, M. (Author), Kanazawa, Y. (Author), Kawanami, D. (Author), Matoba, K. (Author), Nagai, Y. (Author), Nishimura, R. (Author), Sekiguchi, K. (Author), Tachibana, T. (Author), Takahashi, H. (Author), Takeda, Y. (Author), Ukichi, R. (Author), Utsunomiya, K. (Author), Yokota, T. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
albuminuria
Albuminuria
animal
Animals
Diabetes Mellitus, Experimental
Diabetic Nephropathies
diabetic nephropathy
experimental diabetes mellitus
genetics
human
Humans
metabolism
Mice
mouse
podocyte
Podocytes
Rho kinase
rho-Associated Kinases
ROCK2 protein, human
Rock2 protein, mouse
streptozocin
Streptozocin
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