Batf-mediated epigenetic control of effector CD8+ T cell differentiation

Batf-mediated epigenetic control of effector CD8+ T cell differentiation

The response of naive CD8+ T cells to their cognate antigen involves rapid and broad changes to gene expression that are coupled with extensive chromatin remodeling, but the mechanisms governing these changes are not fully understood. Here, we investigated how these changes depend on the basic leuci...

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Bibliographic Details
Main Authors: Barnitz, R.A (Author), DiIorio, M.A (Author), Haining, W.N (Author), Ise, W. (Author), Kaminski, J. (Author), Kurachi, M. (Author), Kurosaki, T. (Author), LaFleur, M.W (Author), Tsao, H.-W (Author), Wherry, E.J (Author), Yosef, N. (Author)
Format: Article
Language:English
Published: American Association for the Advancement of Science 2022
Subjects:
animal
Animals
basic leucine zipper transcription factor
Basic-Leucine Zipper Transcription Factors
Batf protein, mouse
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
cell differentiation
Cell Differentiation
Core Binding Factor Alpha 3 Subunit
Epigenesis, Genetic
female
Female
genetic epigenesis
genetics
immunology
interferon regulatory factor
interferon regulatory factor-4
Interferon Regulatory Factors
knockout mouse
Mice
Mice, Knockout
Mice, Transgenic
mouse
Runx3 protein, mouse
T box transcription factor
T-Box Domain Proteins
T-box transcription factor TBX21
transcription factor RUNX3
transgenic mouse
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