Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma

Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma

Background To characterize genomic determinants of response to pembrolizumab in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) in the KEYNOTE-012 study. Methods Associations between biomarkers (tumor mutational burden (TMB), neoantigen load (NL), 18-gene T-cell-inflamed gen...

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Bibliographic Details
Main Authors: Albright, A. (Author), Ayers, M. (Author), Burtness, B. (Author), Cheng, J. (Author), Chow, L.Q.M (Author), Cristescu, R. (Author), Eder, J.P (Author), Gluck, I. (Author), Gupta, S. (Author), Haddad, R.I (Author), Huang, L. (Author), Kang, H. (Author), Keam, B. (Author), Lunceford, J. (Author), Mehra, R. (Author), Mogg, R. (Author), Muro, K. (Author), Seiwert, T.Y (Author), Tahara, M. (Author), Weiss, J. (Author)
Format: Article
Language:English
Published: BMJ Publishing Group 2022
Subjects:
adult
Antibodies, Monoclonal, Humanized
Antineoplastic Agents, Immunological
Article
assessment of humans
B7-H1 Antigen
cancer patient
cancer recurrence
clinical outcome
cohort analysis
combined positive score
complementary biomarker
ECOG Performance Status
female
Female
gene expression profiling
genetics
head and neck neoplasms
Head and Neck Neoplasms
head and neck squamous cell carcinoma
head and neck tumor
histology
human
Humans
immunohistochemistry
immunological antineoplastic agent
immunotherapy
Immunotherapy
inflammatory biomarker
major clinical study
male
Male
metabolism
monoclonal antibody
neoantigen
outcome assessment
overall survival
pathology
pembrolizumab
peptides and proteins
procedures
programmed cell death 1 receptor
programmed death 1 ligand 1
progression free survival
protein phosphorylation
receiver operating characteristic
single nucleotide polymorphism
Squamous Cell Carcinoma of Head and Neck
T cell inflamed gene expression profile
transcriptome
Transcriptome
tumor biomarkers
Tumor Burden
tumor marker
tumor mutational burden
tumor volume
unclassified drug
whole exome sequencing
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