Application of a novel microscopic technique for quantifying CA125 binding to circulating mononuclear cells in longitudinal specimens during treatment for ovarian cancer

Application of a novel microscopic technique for quantifying CA125 binding to circulating mononuclear cells in longitudinal specimens during treatment for ovarian cancer

Background: Measurement of serum CA125, an antigenic fragment of human mucin 16 (MUC16), is used to monitor the clinical progression of epithelial ovarian cancer (EOC). However, rather than simply a passive marker reflecting tumor burden, MUC16 may have a more active role by binding to immune cells...

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Bibliographic Details
Main Authors: Brooker, J. (Author), Cramer, D.W (Author), Elias, K.M (Author), Evans, C. (Author), Fülöp, V. (Author), González, G. (Author), Hansen, W.P (Author), Hoballah, J. (Author), Jeong, S. (Author), Konstantinopoulos, P.A (Author), Krauledat, P. (Author), Lakatos, K. (Author), Patankar, M. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
algorithm
Algorithms
Antibodies
antibody
antigen binding
Article
B lymphocyte
blood
CA 125 antigen
CA125
CA-125 Antigen
cancer chemotherapy
cancer grading
cancer surgery
Carcinoma, Ovarian Epithelial
female
Female
fluorescence microscopy
fluorescent dye
Fluorescent Dyes
gold
Gold
human
human cell
Humans
immunology
Killer Cells, Natural
Leukocytes, Mononuclear
lymphocyte count
Lymphocyte Count
membrane protein
Membrane Proteins
metabolism
microscopy
Microscopy
Microscopy, Fluorescence
monocyte
monocyte count
Monocytes
mononuclear cell
Mononuclear cells
MUC16 protein, human
mucin
mucin 16
nanoparticle
Nanoparticles
natural killer cell
natural killer T cell
Natural Killer T-Cells
Neoplasm Grading
Ovarian Cancer
Ovarian Neoplasms
ovary cancer
ovary tumor
pathology
platelet count
Platelet Count
procedures
protein binding
protein blood level
thrombocyte
unclassified drug
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