Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging

Aging and exercise have opposing effects on mnemonic discrimination task performance, which putatively taxes pattern separation mechanisms reliant on the dentate gyrus (DG) subfield of the hippocampus. In young adults, increasing cardiorespiratory fitness (CRF) has been shown to improve mnemonic dis...

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Bibliographic Details
Main Authors: Kern, K.L (Author), Schon, K. (Author), Storer, T.W (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
MRI
Online Access:View Fulltext in Publisher
LEADER 03962nam a2200805Ia 4500
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008 220427s2021 CNT 000 0 und d
020 |a 10659471 (ISSN) 
245 1 0 |a Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging 
260 0 |b John Wiley and Sons Inc  |c 2021 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1002/hbm.25259 
520 3 |a Aging and exercise have opposing effects on mnemonic discrimination task performance, which putatively taxes pattern separation mechanisms reliant on the dentate gyrus (DG) subfield of the hippocampus. In young adults, increasing cardiorespiratory fitness (CRF) has been shown to improve mnemonic discrimination task performance and increase left anterior DG/CA3 volume. It is unknown how these variables interact in cognitive aging, yet this knowledge is critical, given the established effects of aging on hippocampal plasticity. To investigate these relationships, 65 older adults (aged 55–85 years) completed a submaximal treadmill test to estimate CRF, a mnemonic discrimination task, and a high-resolution MRI scan to determine hippocampal subfield volumes. Our older adult sample demonstrated the lowest task accuracy in the condition with the greatest stimuli similarity and left DG/CA3 body volume significantly predicted accuracy in this condition. Our results did not provide support for relationships between CRF and task accuracy or CRF and DG/CA3 volume as evidenced in studies of young adults. Instead, CRF predicted bilateral subiculum volume in older adult women, not men. Altogether, these findings provide further support for a role of the DG in behavioral pattern separation in humans and suggest that CRF may have differential effects on hippocampal subfield integrity in older adult men and women. ClinicalTrials.gov identifiers: (a) Neuroimaging Study of Exercise and Memory Function, NCT02057354; (b) The Entorhinal Cortex and Aerobic Exercise in Aging, NCT02775760; (c) Physical Activity and Cognition Study, NCT02773121. © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. 
650 0 4 |a adult 
650 0 4 |a aerobic exercise 
650 0 4 |a aged 
650 0 4 |a Aged 
650 0 4 |a Aged, 80 and over 
650 0 4 |a aging 
650 0 4 |a aging 
650 0 4 |a aging 
650 0 4 |a Aging 
650 0 4 |a anatomy and histology 
650 0 4 |a article 
650 0 4 |a body volume 
650 0 4 |a CA3 Region, Hippocampal 
650 0 4 |a cardiorespiratory fitness 
650 0 4 |a cardiorespiratory fitness 
650 0 4 |a cardiorespiratory fitness 
650 0 4 |a Cardiorespiratory Fitness 
650 0 4 |a clinical trial 
650 0 4 |a dentate gyrus 
650 0 4 |a Dentate Gyrus 
650 0 4 |a diagnostic imaging 
650 0 4 |a discrimination learning 
650 0 4 |a Discrimination Learning 
650 0 4 |a entorhinal cortex 
650 0 4 |a female 
650 0 4 |a Female 
650 0 4 |a hippocampal CA3 region 
650 0 4 |a hippocampal CA3 region 
650 0 4 |a hippocampus 
650 0 4 |a human 
650 0 4 |a human experiment 
650 0 4 |a Humans 
650 0 4 |a Magnetic Resonance Imaging 
650 0 4 |a male 
650 0 4 |a Male 
650 0 4 |a memory 
650 0 4 |a middle aged 
650 0 4 |a Middle Aged 
650 0 4 |a mnemonic discrimination 
650 0 4 |a MRI 
650 0 4 |a neuroimaging 
650 0 4 |a nuclear magnetic resonance imaging 
650 0 4 |a nuclear magnetic resonance imaging 
650 0 4 |a pattern separation 
650 0 4 |a physical activity 
650 0 4 |a physiology 
650 0 4 |a sex factor 
650 0 4 |a Sex Factors 
650 0 4 |a subiculum 
650 0 4 |a task performance 
650 0 4 |a Task Performance and Analysis 
650 0 4 |a treadmill test 
650 0 4 |a very elderly 
650 0 4 |a young adult 
700 1 |a Kern, K.L.  |e author 
700 1 |a Schon, K.  |e author 
700 1 |a Storer, T.W.  |e author 
773 |t Human Brain Mapping