Panax quinquefolius (North American ginseng) cell suspension culture as a source of bioactive polysaccharides: Immunostimulatory activity and characterization of a neutral polysaccharide AGC1

Panax quinquefolius (North American ginseng) cell suspension culture as a source of bioactive polysaccharides: Immunostimulatory activity and characterization of a neutral polysaccharide AGC1

In this study, we propose the use of a plant tissue culture-based system for the production of polysaccharides with consistent chemical characteristics and reduced endotoxin content. Polysaccharides were isolated from suspension cultures of Panax quinquefolius (American ginseng), a widely used medic...

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Bibliographic Details
Main Authors: Altman, E. (Author), Arivett, B.A (Author), Bowling, J.L (Author), Bryant, D.L (Author), DuBois, J.D (Author), Farone, A.L (Author), Fuller, M.L (Author), Ghosh, R. (Author), Hayes, D. (Author), Kline, P.C (Author), Nelson, D.E (Author), Nwangwa, E.E (Author), Smith, S.A (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2019
Subjects:
animal
animal cell
Animals
anion exchange
arabinose
Article
cell culture
cell proliferation
cell suspension
Cells, Cultured
chemical composition
chemistry
conditioned medium
controlled study
Culture Media, Conditioned
cytokine
cytokine production
Cytokines
cytology
drug determination
drug effect
ex vivo study
galactose
gene
gene expression
glucose
granulocyte macrophage colony stimulating factor
immunologic factor
Immunologic Factors
immunology
immunomodulation
Immunomodulation
immunostimulation
in vitro study
interleukin 6
isolation and purification
live cell imaging
macrophage
Macrophages
mannose
mass fragmentography
metabolism
Mice
molecular weight
Molecular Weight
monocyte chemotactic protein 1
mouse
MTT assay
nitric oxide
Nitric Oxide
nonhuman
NOS2 gene
NOS2 reporter
Panax
Panax quinquefolius
Panax quinquefolius extract
pharmacology
phytochemical
Phytochemicals
plant extract
Plant Extracts
polysaccharide
Polysaccharides
protein expression
RAW 264.7 cell line
RAW 264.7 Cells
rhamnose
size exclusion chromatography
spleen cell
Suspension culture polysaccharides
tumor necrosis factor
unclassified drug
Western blotting
xylose
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