Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice

Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice

The spike (S) protein is a leading vaccine candidate against SARS-CoV-2 infection. The S1 domain of S protein, which contains a critical receptor-binding domain (RBD) antigen, potentially induces protective immunoreactivities against SARS-CoV-2. In this study, we presented preclinical evaluations of...

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Bibliographic Details
Main Authors: Chang, T.-Y (Author), Chen, C.-C (Author), Chen, X.-A (Author), Chiao, D.-J (Author), Kuo, S.-C (Author), Lin, H.-T (Author), Young, J.-J (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
Adjuvants, Immunologic
animal
animal cell
animal experiment
animal model
Animals
Antibodies, Viral
antibody titer
antigenicity
Article
Bagg albino mouse
Broadly Neutralizing Antibodies
chemistry
controlled study
coronavirus spike glycoprotein
COVID-19 Vaccines
CpG adjuvant
CpG oligodeoxynucleotide
CPG-oligonucleotide
drug formulation
drug synthesis
enzyme linked immunosorbent assay
female
Fucoidan-trimethylchitosan nanoparticles
human
human cell
humoral immunity
Immunogenicity enhancement
Immunogenicity, Vaccine
immunoglobulin G1 antibody
immunoglobulin G2a antibody
immunoglobulin G2b
immunological adjuvant
immunology
immunoreactivity
Mice
Mice, Inbred BALB C
mouse
nanoparticle
Nanoparticles
Neutralizing antibody
nonhuman
oligodeoxyribonucleotide
Oligodeoxyribonucleotides
particle size
pharmacology
photon correlation spectroscopy
recombinant protein
Recombinant S1 protein
SARS-CoV-2
SARS-CoV-2 infection
SARS-CoV-2 recombinant S1 protein
SARS-CoV-2 vaccine
Spike Glycoprotein, Coronavirus
Th1 cell
Th1 Cells
Th1-biased cellular immune responses
unclassified drug
vaccine immunogenicity
variant of concern
virus antibody
virus neutralization
Western blotting
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