Double positivity for HPV-DNA/p16ink4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients

Double positivity for HPV-DNA/p16ink4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients

Background: The etiologic role of human papillomaviruses (HPV) in oropharyngeal cancer (OPC) is well established. Nevertheless, information on survival differences by anatomic sub-site or treatment remains scarce, and it is still unclear the HPV-relatedness definition with best diagnostic accuracy a...

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Bibliographic Details
Main Authors: Aguila, A. (Author), Alejo, M. (Author), Alemany, L. (Author), Bagué, S. (Author), Blazquez, C. (Author), Bonfill, T. (Author), Bosch, F.X (Author), Bravo, I.G (Author), Clavero, O. (Author), de Sanjosé, S. (Author), Gomà, M. (Author), Guix, M. (Author), Hijano, R. (Author), Holzinger, D. (Author), Leon, X. (Author), Lloveras, B. (Author), Marquez, S. (Author), Mena, M. (Author), Mesia, R. (Author), Nogués, J. (Author), Pavon, M.A (Author), Pawlita, M. (Author), Quer, M. (Author), Quiros, B. (Author), Taberna, M. (Author), Torres, M. (Author), Tous, S. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
Alphapapillomavirus
antineoplastic agent
Article
Biomarkers, Tumor
cancer diagnosis
cancer prognosis
cancer radiotherapy
cancer recurrence
cancer survival
chemoradiotherapy
cisplatin
cohort analysis
cyclin D1
cyclin dependent kinase inhibitor 2A
Cyclin-Dependent Kinase Inhibitor p16
diagnostic accuracy
Diagnostic accuracy
diagnostic test accuracy study
DNA, Viral
follow up
genetics
genotype
human
Human papillomavirus
Humans
immunohistochemistry
induction chemotherapy
isolation and purification
Kaplan Meier method
Kaplan-Meier Estimate
major clinical study
messenger RNA
metabolism
nonhuman
Oropharyngeal cancer
Oropharyngeal Neoplasms
oropharynx cancer
oropharynx carcinoma
oropharynx tumor
overall survival
pathology
priority journal
prognosis
Prognosis
Prognosis markers
protein E6
protein expression
protein p53
random sample
recurrent disease
retinoblastoma protein
Retrospective Studies
retrospective study
sensitivity and specificity
Survival
tumor marker
virology
virus DNA
Wart virus
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