Hypoxia modulates CCR7 expression in head and neck cancers

Background: The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and...

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Bibliographic Details
Main Authors:	Afarinkia, K. (Author), Basheer, H.A (Author), Cooper, P.A (Author), Hunter, K.D (Author), Martin, L. (Author), Pakanavicius, E. (Author), Shnyder, S.D (Author), Vinader, V. (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Subjects:	animal animal experiment animal model Animals Article Bagg albino mouse Biomarkers, Tumor cancer cell culture CCR7 CCR7 protein, human cell hypoxia Cell Hypoxia Cell Line, Tumor chemokine receptor CCR7 controlled study female Female genetics head and neck cancer Head and neck cancer head and neck cancer cell line Head and Neck Neoplasms head and neck tumor HIF-1α human human cell human tissue Humans hypoxia Hypoxia hypoxia inducible factor 1alpha Hypoxia-Inducible Factor 1, alpha Subunit in vitro study in vivo study major clinical study metabolism Mice Mice, Inbred BALB C Mice, Nude mouse multicellular spheroid nonhuman nude mouse OSC-19 cell line pathology priority journal protein analysis protein expression Receptors, CCR7 tissue microarray tumor cell line tumor marker tumor xenograft Tumour grade Tumour stage
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Hypoxia modulates CCR7 expression in head and neck cancers

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